Prof. Hiroaki Sasai
The Institute of Scientific and Industrial Research (ISIR), Osaka University, Japan
Title: Highly enantioselective oxidative coupling of polycyclic phenols using a chiral vanadium(V) catalyst
Abstract:
We have reported enantioselective oxidative coupling of 2-naphthos 2 catalyzed by a chial dinuclear vanadium(V) complex (Ra,S,S)-1.1Recentry we found newly developed mononuclear catalyst (Ra,S)-4 was effective for the oxidative coupling of polycyclic phenol 5 to produce oxa[9]helicenes 6 via an oxidative coupling/intramolecular cyclization.2 Application of catalyst 1 for a short step synthesis of carbazole alkaloid,sorazolon E2, will also be discussed.3
1. a) Takizawa, S.; Katayama, T.; Sasai, H. Chem. Commun. 2008, 4113. b) Sako, M.; Takizawa, S.; Sasai, H. Tetrahedron: Asymmetry, 2015, 26, 613.
2. Sako, M.; Takeuchi, Y.; Tsujihara, T.; Kodera, J.; Kawano, T.; Takizawa, S.; Sasai, H. J. Am. Chem. Soc.2016, 138, 11481.
3. Sako, M.; Ichinose, K.; Takizawa, S.; Sasai, H. Chem. Asian J. 2017, in press.
Biography:
Hiroaki Sasai received his doctor degree in 1985 from Keio University. After working as a researcher at Sagami Chemical Research Center for three years,he joined Prof. Shibasaki’s group at Hokkaido University as an assistant professor. In 1992, he moved to the University of Tokyo (lecturer and then associate professor), and in 1997 he was appointed as a full professor of the Institute of Scientific and Industrial Research (ISIR), Osaka University. He was a recipient of 1995 Pharmaceutical Society of Japan Award for Young Scientists and the Fluka Prize "Reagent of the Year 1996". He received The Chemical Society of Japan Award for Creative Work and Ichimura Science Award in 2006, the Molecular Chirality Award in 2011, and Synthetic Organic Chemistry Award in 2016.